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Though it is a versatile biomaterial, silicone\u2010based devices are still challenged by implant\u2010associated infections and fibrous capsule formation complications. Here, a NO\u2010generating (NOgen) interface is developed from copper or strontium\u2010doped mesoporous bioactive glass\u2010based coating on silicone substrates to facilitate metal\u2010ion catalysis of endogenous S\u2010nitrosothiols. The copper or strontium\u2010based interfaces can generate physiologically relevant NO levels, which have bactericidal and antithrombotic effects to combat implant\u2010associated early onsite infection and thrombosis. The NO generated in tandem with the low therapeutic release of strontium ions from the NOgen interface regulates cellular fate pertaining to fibroblasts, macrophages, and endothelial cells. Strontium suppresses the collagen expression and migration of activated fibroblasts while favoring M\n                    <jats:sub>2<\/jats:sub>\n                    phenotype bias in macrophages. Differential NO flux observed over time from NOgen interfaces helps switch macrophages from proinflammatory M\n                    <jats:sub>1<\/jats:sub>\n                    phenotype to M\n                    <jats:sub>2<\/jats:sub>\n                    anti\u2010inflammatory phenotype. Moreover, the synergistic effect of leachate and NO generated by the silicone substrate demonstrates a proangiogenic effect by aiding endothelial network maturation in vitro. Thus, the multifunctional features of the developed strontium\u2010doped bioactive glass\u2010based coating hold promise in regulating local immune\u2010micromilieu and attenuating implant\u2010associated fibrosis of silicone\u2010based implantable devices.\n                  <\/jats:p>","DOI":"10.1002\/smll.202411984","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T23:39:39Z","timestamp":1740526779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["In Situ Nitric Oxide Generating Nano\u2010Bioactive Glass\u2010Based Coatings and Its Therapeutic Ion Release toward Attenuating Implant\u2010Associated Fibrosis and Infection"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-8196","authenticated-orcid":false,"given":"Joseph Christakiran","family":"Moses","sequence":"first","affiliation":[{"name":"School of Chemical Materials and 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