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Herein, a hybrid compartmentalized architecture via hybridizing ferritin nanocage (Fn) with non\u2010aqueous droplets using aminated\u2010modified amphiphilic gelatin (AGEL) is proposed, which enables the generation of compartmentalized emulsions with hybrid multicompartments. The resulting compartmentalized emulsions are termed \u201chybrasome\u201d. Specifically, by chemically attaching ethylenediamine to gelatin, the programmed noncovalent docking of Fn\u2010AGEL nanoparticles is implemented and their interfacial self\u2010rearrangement generates hybrasome with layered physicochemical barriers. Confocal Laser Scanning Microscopy images show that Fn nanocages are deposited on the non\u2010aqueous droplets, separated by gelatin layers. Interfacial adsorption kinetics reveal that lower permeation and rearrangement rates of Fn are responsible for their double\u2010layered structure formation. By choosing oxidized iron nanoparticles and reductant carnosic acid (CA) as models, these two molecules are co\u2010encapsulated separately within the hybrasome, resulting in significant inhibition of the redox reaction. After structural destruction in the intestine, a redox reaction is triggered and leads to the Fe<jats:sup>2+<\/jats:sup> redox products release, which generates a suitable valence state of iron element for cell absorption. Overall, this approach may open up an avenue for facile construction of hybrid compartmentalized architectures used to co\u2010encapsulate incompatible compounds separately and control the sequential release of targeted components.<\/jats:p>","DOI":"10.1002\/smll.202412033","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T15:04:31Z","timestamp":1741791871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interfacial\u2010Design Mediated Construction of Hybrid Multicompartment Architectures with Layered Physicochemical Barriers for Separately Sequestration of Oxidation\u2013Reduction Molecules and Their Redox Reaction Regulation"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-8411","authenticated-orcid":false,"given":"Hai","family":"Chen","sequence":"first","affiliation":[{"name":"College of Food Science Southwest University  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