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This study presents an innovative dissolvable microneedle (MN) patch incorporating Au@ZnO\/Ce nanocomposites and vancomycin (AZC\/Van@MN), exhibiting robust antimicrobial and anti\u2010inflammatory properties, meticulously engineered for the therapeutic intervention of abscess wounds. The developed AZC\/Van@MN patch demonstrates exceptional biocompatibility as evidenced by comprehensive histopathological and hematological assessments. It effectively eradicates bacterial colonies through the synergistic action of Van and mild photothermal therapy (PTT, \u226442\u00a0\u00b0C). Transcriptomic analysis elucidates that the antibacterial mechanism involves the upregulation of riboflavin biosynthesis and the suppression of arginine biosynthesis pathways. Furthermore, AZC\/Van@MN significantly reduces abscess dimensions, bacterial load, and inflammatory response, while simultaneously enhancing wound healing via accelerated re\u2010epithelialization and angiogenesis. This double\u2010edged MN patch represents a promising strategy for combating skin abscesses instigated by antibiotic\u2010resistant bacteria.<\/jats:p>","DOI":"10.1002\/smll.202412165","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T11:18:57Z","timestamp":1739704737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Double\u2010Edged Dissolving Microneedle Patches Loaded with Zn\/Ce Composites and Vancomycin for Treatment of Drug\u2010Resistant Bacterial Infected Skin Abscess"],"prefix":"10.1002","volume":"21","author":[{"given":"Yu","family":"Jin","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University  Hefei Anhui 230032 P. R. 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