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However, most of patients with malignant cancer receiving traditional therapies have tumor recurrence and short\u2010term 5\u2010year survival. Herein, a novel Cu\n                    <jats:sub>2<\/jats:sub>\n                    O\u2010MnO@PEG (CMP) nanomaterial is developed to treat tumors. CMP directly mediates cuproptosis in tumor cells. Meanwhile, CMP potentiates anti\u2010tumor immune responses in the tumor microenvironment (TME) to induce tumor regression. CMP improves the tumor antigen processing and presentation of dendritic cells and tumor\u2010associated macrophages, and further promotes CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses, especially for cytotoxic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and transitory exhausted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Additionally, CMP downregulates the proportion of Treg cells and CTLA\u20104 expression on Treg cells. Notably, CMP induces systemic immune responses against distant tumors and long\u2010term immune memory. Furthermore, CMP synergized with PD\u2010L1 mAb promotes tumor inhibition and sustains the anti\u2010tumor efficacy post PD\u2010L1 mAb treatment. Collectively, this strategy has the clinically therapeutic potential for tumors by facilitating cuproptosis in tumor cells and anti\u2010tumor immune responses.\n                  <\/jats:p>","DOI":"10.1002\/smll.202412174","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T09:29:06Z","timestamp":1739698146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Copper\u2010Manganese Based Nanocomposite Induces Cuproptosis and Potentiates Anti\u2010Tumor Immune Responses"],"prefix":"10.1002","volume":"21","author":[{"given":"Luoyingzi","family":"Xie","sequence":"first","affiliation":[{"name":"Institute of Hepatopancreatobiliary Surgery Chongqing General Hospital Chongqing University  Chongqing 401147 P. R. China"},{"name":"Chongqing Key Laboratory of Intelligent Medicine Engineering for Hepatopancreatobiliary Diseases  Chongqing 401147 P. R. 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