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Herein, the efficient synthesis of well\u2010defined multi\u2010responsive hydrophilic hairy fluorescent molecularly imprinted polymer (MIP) nanocapsules is reported to address this issue, which have a disulfide\u2010crosslinked fluorescent MIP shell with sialic acid (SA, generally overexpressed on tumor cells)\u2010imprinted binding sites, some poly(methacrylic acid) chains inside cavities, and surface\u2010grafted (via dynamic benzoic\u2010imine bond) block copolymer brushes with a thermo\/pH\u2010responsive (collapse\/stretching) inner block and a hydrophilic outer block. They show excellent aqueous dispersity, good bio\/hemocompatibility, and tumor\u2010microenvironment\u2010triggered detachment of polymer brushes (allowing exposure of SA\u2010imprinted sites and negative\u2010to\u2010positive surface charge reversal) and (glutathione\u2010induced) degradation. Particularly, they also exhibit integrated properties of an ultrahigh antitumor drug (5\u2010fluorouracil) loading capacity (688\u00a0\u00b5mol g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), negligible premature drug release, largely prolonged blood circulation, specific and sustainable tumor site accumulation, enhanced tumor penetration, and rapid drug release inside tumor cells, which enable them to significantly inhibit tumor growth inside mice. This study opens new access for well\u2010tailored smart \u201call\u2010in\u2010one\u201d\u2010type drug carriers as a versatile nanoplatform for various cancer therapies by simply loading different or multiple drugs.\n                  <\/jats:p>","DOI":"10.1002\/smll.202412303","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T06:56:44Z","timestamp":1746601004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multi\u2010Responsive Molecularly Imprinted Polymer Nanocapsules as Biological Environment\u2010Adaptable Drug Carriers for Efficient Cancer Therapy"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-691X","authenticated-orcid":false,"given":"Huiqi","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials (Ministry of Education) 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