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Reactive oxygen species (ROS), especially hydrogen peroxide (H\u2082O\u2082), significantly drive hepatocyte injury, initiating oxidative stress and inflammation. Current antioxidants, such as N\u2010acetylcysteine (NAC) and superoxide dismutase (SOD), show limited clinical efficacy due to poor targeting, instability, and toxicity. Catalase (CAT), an essential enzyme for H\u2082O\u2082 decomposition, represents a promising therapeutic for ALI; however, its clinical application faces challenges in stability, rapid degradation, and insufficient targeting. Here, a novel nanocapsule\u2010based CAT delivery system (n(CAT)) is presented, formed through in situ radical polymerization using 2\u2010methacryloyloxyethyl phosphorylcholine (MPC) and N\u2010(3\u2010aminopropyl)\u2010methacrylamide hydrochloride (APM). This strategy significantly enhances CAT's stability, retains enzyme activity, and improves selective liver accumulation, particularly at inflammation sites. The results demonstrate that n(CAT) effectively reduces oxidative stress, minimizes inflammation, and facilitates liver repair in ALI and ischemia\u2010reperfusion injury (IRI) models. These findings highlight the potential of n(CAT) as a promising platform for advanced antioxidant therapies targeting liver diseases, including hepatitis.<\/jats:p>","DOI":"10.1002\/smll.202412349","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:17:58Z","timestamp":1745569078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Polymer\u2010Encapsulated Catalase for Targeted Redox Regulation in Acute Liver Injury"],"prefix":"10.1002","volume":"21","author":[{"given":"Feifei","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingqi","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeren","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University Tongji Shanxi Hospital  Taiyuan 030032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"He","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University Tongji Shanxi Hospital  Taiyuan 030032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Li","sequence":"additional","affiliation":[{"name":"University of California  Santa Barbara California 93106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u2010Ding","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University Guangzhou  Guangdong 510632 P. R. China"},{"name":"Clinical Neuroscience Institute The First Affiliated Hospital of Jinan University  Guangzhou 510632 P. R. 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