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Methotrexate (MTX) is the standard first\u2010line treatment for RA, but its clinical application is hindered by poor water solubility and non\u2010specific delivery. In this work, a multifunctional drug\u2010delivery nanoplatform that targets both macrophages and tumor necrosis factor \u03b1 (TNF\u03b1) is developed to enhance the therapeutic efficacy of MTX in RA. The nanoplatform consists of folic acid (FA, for macrophage targeting) and a TNF\u03b1\u2010specific Aptamer (TNF\u03b1\u2010Apt), facilitating a dual\u2010targeting strategy that significantly improves the accumulation of MTX at the sites of RA lesions (\u22483.5\u2010fold). Moreover, the manganese dioxide (MnO\u2082) and polydopamine (PDA) coatings on the nanoplatform effectively scavenge reactive oxygen species (ROS), generate oxygen, and promote the polarization of pro\u2010inflammatory M1 macrophages to the anti\u2010inflammatory M2 macrophages. 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