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However, its short half\u2010life of \u224820 min leads to poor patient compliance and increased medical burden. Here, a long\u2010acting anticoagulant hydrogel based on Biva for antithrombotic treatment is described. The fusion peptide (\n                    <jats:sc>d<\/jats:sc>\n                    \u2010RADA)8\u2010B that integrates Biva, a D\u2010type self\u2010assembly motif, and an activated factor X\u00a0(FXa)\u2010responsive motif exhibits both supramolecular reservoir and prodrug\u2010like properties. After subcutaneous injection, the anticoagulant peptide forms a semi\u2010solid depot with protease\u2010degradation resistance and slowly disassembles to release prodrug (\n                    <jats:sc>d<\/jats:sc>\n                    \u2010RADA)8\u2010B into the bloodstream. The circulating prodrug acts as an inert sentinel, which can be activated to release Biva to inhibit thrombus formation when exposed to the thrombus\u2010related protease FXa. One week after the administration of (\n                    <jats:sc>d<\/jats:sc>\n                    \u2010RADA)8\u2010B, significant embolism suppression is observed in animal models of carotid artery thrombosis and pulmonary embolism without increasing hemorrhagic side effects. This study demonstrates a concise strategy to engineer a supramolecular anticoagulant hydrogel with long\u2010term, high drug loading, and on\u2010demand antithrombotic activation.\n                  <\/jats:p>","DOI":"10.1002\/smll.202500193","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:37:25Z","timestamp":1747669045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Supramolecular Prodrug Hydrogel for One\u2010Week Protection Against Thrombosis"],"prefix":"10.1002","volume":"22","author":[{"given":"Wenjing","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Nanjing Tech University  Nanjing 211816 China"},{"name":"School of Biotechnology and Pharmaceutical Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Pharmaceutical Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Pharmaceutical Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-0951","authenticated-orcid":false,"given":"Tianyue","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315754"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00552-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000818"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0061-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01999-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02162-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","DOI":"10.1177\/10760296211055165","volume":"27","author":"Li S.","year":"2021","journal-title":"Clin. 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