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Herein, a self\u2010powered miniaturized biosensor (SPB) based on an enzyme biofuel cell is constructed to monitor H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. This SPB significantly minimized the use of bioenzymes that often experience instability and lead to the high cost of biosensors. More specifically, a composite of polydopamine (PDA)\u2010gold nanoparticles (AuNPs) is prepared as an anodic catalyst scaffold to immobilize glucose oxidase to efficiently catalyze the oxidation of glucose (fuel) due to its excellent biocompatibility and electrical conductivity. Upon the incorporation of CuCoP with a polyoxometalate H<jats:sub>3<\/jats:sub>PW<jats:sub>12<\/jats:sub>O<jats:sub>40<\/jats:sub> (PW<jats:sub>12<\/jats:sub>), a nanoenzyme of CuCoP\u2010PW<jats:sub>12<\/jats:sub> composite is realized as a non\u2010biological cathodic catalyst to replace the conventional cathode enzymes for the reduction of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. The abundant catalytic active sites on CuCoP\u2010PW<jats:sub>12<\/jats:sub> and high electron transfer rate of PW<jats:sub>12<\/jats:sub> result in a high catalytic activity toward H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> reduction at the cathode. Owing to a good synergy between the bioanode and abiotic\u2010cathode, the prepared SPB exhibits two linear ranges (2\u201320 and 20\u201350 \u00b5<jats:sc>m<\/jats:sc>) and a low detection limit (0.0589 \u00b5<jats:sc>m<\/jats:sc>) toward H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> detection. Upon the use of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> as a model analyte, this work demonstrates that SPB can be effectively applied in biomedical sensing.<\/jats:p>","DOI":"10.1002\/smll.202500451","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:38:33Z","timestamp":1746175113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Self\u2010Powered Biosensor Driven by a Hybrid Biofuel Cell with CuCoP\u2010Polyoxometallate Composite as Both Cathode Catalyst and Sensing Interface"],"prefix":"10.1002","volume":"21","author":[{"given":"Jiaojiao","family":"Liu","sequence":"first","affiliation":[{"name":"Henan International Joint Laboratory of Medicinal Plants Utilization College of Chemistry and Molecular Sciences Henan University  Zhengzhou 450046 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