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However, their widespread application is hindered by concerns related to material safety and hemostatic efficacy. In this study, a hemostatic aerogel composed of cellulose nanofibers (CNFs) and Calcium ion\u2010exchanged nanoporous zeolite is developed. CNFs facilitate the in\u2010situ synthesis of nanoporous zeolites, and the zeolites are firmly embedded within the aerogel through abundant hydrogen bonds. Notably, the zeolite loading in the aerogel is only 2.89 wt.%, significantly lower than the 18.76 wt.% kaolin content in QuikClot combat gauze. Despite the low loading, the nanoporous zeolites exhibit high efficiency in promoting prothrombin\u2010to\u2010thrombin conversion and accelerating blood clotting. The reduced zeolite content, combined with its strong binding to the aerogel matrix, minimizes the risks of exothermic burns and detached particle\u2010induced distal thrombosis. The animal experiments reveal that the aerogel rapidly controls severe femoral artery bleeding and substantially reduces blood loss. This study presents a novel formulation of zeolite\u2010based hemostatic materials, offering remarkable improvements in both safety and efficacy.<\/jats:p>","DOI":"10.1002\/smll.202500696","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T04:49:15Z","timestamp":1744001355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nanoporous Zeolite Anchored Cellulose Nanofiber Aerogel for Safe and Efficient Hemostasis"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-223X","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University  Shanghai 200241 P. R. 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