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Disulfidptosis, a newly identified form of programmed cell death (PCD), occurs in cells with high\n                    <jats:italic>x<\/jats:italic>\n                    CT\/SLC7A11 expression under glucose\u2010deprived conditions. Distinct from other PCD pathways, disulfidptosis is characterized by aberrant disulfide bond formation and cellular dysfunction, ultimately resulting in cancer cell death. This novel mechanism offers remarkable therapeutic potential by targeting the inherent oxidative stress vulnerabilities of rapidly growing cancer cells. Advances in nanotechnology enable the development of nanomaterials capable of inducing reactive oxygen species (ROS) generation, disrupting disulfide bonds. In addition, they are capable to deliver therapeutic agents directly to tumors, thereby improving therapeutic precision and minimizing off\u2010target effects. Moreover, combining\u00a0disulfidptosis with ROS\u2010induced immunogenic cell death can remodel the tumor microenvironment and enhance anti\u2010tumor immunity. This review explores the mechanisms underlying disulfidptosis, its therapeutic potential in cancer treatment, and the synergistic role of nanotechnology in amplifying its effects. Selective induction of disulfidptosis using nanomaterials represents a promising strategy for achieving more effective, selective, and less toxic cancer therapies.\n                  <\/jats:p>","DOI":"10.1002\/smll.202500880","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:20:20Z","timestamp":1745464820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Unlocking the Potential of Disulfidptosis: Nanotechnology\u2010Driven Strategies for Advanced Cancer Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Wenyao","family":"Zhen","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore  Singapore 119074 Singapore"},{"name":"Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore  Singapore 117599 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