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Thus the one\u2010pot assembly of highly integrated multifunctional antibacterial agents is highly desirable for treating multidrug\u2010resistant (MDR) bacteria. Herein, the vancomycin\u2010derived carbon dots (Van\u2010CDs) are facilely developed as a compact and powerful multifunctional photodynamic nanozyme platform that achieves the augmented reactive oxygen species (ROS) generation for accelerating bacterial elimination. By residual recognition groups of vancomycin, the red emissive Van\u2010CDs gain a specific affinity toward bacteria with a high binding constant of 20\u00a0L\u00a0g<jats:sup>\u22121<\/jats:sup>, manifesting a superior bacteria\u2010imaging ability. 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