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Developing effective treatments to eliminate resistant bacteria from the bloodstream, simultaneously mitigate infection\u2010related complications, and reduce mortality remains challenging. Herein, microspheres are synthesized with bacterial elimination and inflammation prevention by crosslinked sulfonium poly(amino acids). As\u2010synthesized microsphere, PM\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>0.6B<\/jats:sup>\n                    \u00a0MS, exhibits an ultrafast adsorption efficiency of 0.41 \u00d7 10\n                    <jats:sup>8<\/jats:sup>\n                    CFU mg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    for MRSA, which positions the highest index among the reported resin and inorganic adsorptions. This bacterial\u2010specific and efficient capture of PM\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>0.6B<\/jats:sup>\n                    \u00a0MS is attributed to its strong interactions with teichoic acids in MRSA (Ka: 1.8 \u00d7 10\n                    <jats:sup>5<\/jats:sup>\n                    \u00a0M\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) rather than acting with phospholipids of mammalian cells. Unlike the present resin\u2010based adsorbent, for example, heparin\u2010modified polyethylene in the only commercial Seraph\n                    <jats:sup>\u00ae<\/jats:sup>\n                    100, PM\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>0.6B<\/jats:sup>\n                    \u00a0MS kills adsorbed bacteria within 1\u00a0h and can be reused by simple treatment. Meanwhile, PM\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>0.6B<\/jats:sup>\n                    \u00a0MS also shows good hemocompatibility and longer thrombin activation time to reduce the risk of thrombosis and hemolysis. In vivo experiments further confirm the abilities of PM\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>0.6B<\/jats:sup>\n                    \u00a0MS to prevent inflammation by removing bacteria. This adsorbent is a promising candidate for early treating life\u2010threatening bloodstream infections, potentially preventing bacteremia and subsequent organ damage.\n                  <\/jats:p>","DOI":"10.1002\/smll.202501298","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T02:31:16Z","timestamp":1744597876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bacterial Specific Recognition of Sulfonium Poly(Amino Acid) Adsorbents for Ultrafast MRSA Capture Against Bloodstream Infection"],"prefix":"10.1002","volume":"21","author":[{"given":"Zhenyan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LOFE) &amp; Institute of Flexible Electronics (IFE) Shaanxi Key Laboratory of Flexible Electronics and MIIT Key Laboratory of Flexible Electronics (KLoFE) Northwestern Polytechnical University  127 West Youyi Road Xi'an 710072 P. R. China"},{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. 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