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Here, catalase (CAT)\u2010containing microreactor capsules with long\u2010lasting broad\u2010spectrum ROS\/RNS\u2010scavenging capability are developed for the treatment of IBD. In this design, CAT is encapsulated in the dense hydrogel network of calcium alginate (ALG) microspheres, which provides long\u2010term protection of CAT activity in protease\u2010rich intestinal environment. Afterward, the polydopamine (PDA) modification on the surface of CAT@ALG microspheres can provide them bioadhesiveness to achieve prolonged retention in the intestinal tract and broad\u2010spectrum scavenging capability against various types of ROS\/RNS beyond hydrogen peroxide. Enteric capsules are further used to protect the CAT@ALG\u2013PDA microspheres from gastric fluid for selective release at the intestinal site. The combined action of PDA and CAT in CAT@ALG\u2013PDA microreactors results in the broad\u2010spectrum scavenging of excess ROS\/RNS and regulates redox balance in acute UC rat model, showing satisfactory therapeutic effects superior to the mesalazine and adalimumab at clinically relevant doses without obvious side effects. This work highlights that these CAT@ALG\u2013PDA capsules can act as long\u2010acting broad\u2010spectrum ROS\/RNS reactors, promising for IBD treatment.<\/jats:p>","DOI":"10.1002\/smll.202501341","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T01:24:31Z","timestamp":1745371471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Broad\u2010Spectrum ROS\/RNS Scavenging Catalase\u2010Loaded Microreactors for Effective Oral Treatment of Inflammatory Bowel Diseases"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9723-2752","authenticated-orcid":false,"given":"Xiangyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials &amp; Devices Soochow University  199 Ren'ai Road Suzhou Jiangsu 215123 P. R. 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