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To address this challenge, the study successfully fabricates a heterojunction MoS\n                    <jats:sub>2<\/jats:sub>\n                    @Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    with exceptional piezoelectric properties through doping engineering. Comprehensive studies reveal that MoS\n                    <jats:sub>2<\/jats:sub>\n                    @Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    efficiently converts mechanical energy into electrical energy, facilitates hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) evolution, and enhances the antioxidant enzyme\u2010like performances under ultrasonic irradiation. Moreover, a GSH and GSSG switch cycle is established during the piezocatalytic process, which is conducive to augment the piezoelectricity of MoS\n                    <jats:sub>2<\/jats:sub>\n                    @Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    in biological environment. Further investigations demonstrate that deformation of MoS\n                    <jats:sub>2<\/jats:sub>\n                    @Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    significantly reduced the free energy required for \u2022OH adsorption, thereby dramatically enhancing its \u2022OH scavenging ability. Both experimental and theoretical results verify a narrowed bandgap of MoS\n                    <jats:sub>2<\/jats:sub>\n                    @Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    with or without deformation, indicating that the alteration in bandgap is fundamentally responsible for the enhanced piezoelectric effect, piezocatalytic properties, and H\n                    <jats:sub>2<\/jats:sub>\n                    evolution. Capitalizing on the antioxidant capability of H\n                    <jats:sub>2<\/jats:sub>\n                    and MoS\n                    <jats:sub>2<\/jats:sub>\n                    @Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    itself, the developed MoS\n                    <jats:sub>2<\/jats:sub>\n                    @Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    exhibits anti\u2010inflammation activity both in vitro and in vivo, suggesting their potential for the treatment of rheumatoid arthritis and other inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.202501551","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T03:36:00Z","timestamp":1747971360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Augmenting Antioxidant Enzyme\u2010Like Activity and Hydrogen Evolution of MoS\n                    <sub>2<\/sub>\n                    @Bi\n                    <sub>2<\/sub>\n                    S\n                    <sub>3<\/sub>\n                    Heterojunction via Ultrasound\u2010Evoked Piezoelectricity for Anti\u2010Inflammation"],"prefix":"10.1002","volume":"21","author":[{"given":"Jingnan","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishuo","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 P. R. China"},{"name":"Henan Key Laboratory of Nanomedicine for Targeting Diagnosis and Treatment  Zhengzhou 450001 P. R. China"},{"name":"Key Laboratory of Advanced Drug Preparation Technologies Ministry of Education of China Zhengzhou University  Zhengzhou 450001 P. R. 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