{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:57:23Z","timestamp":1786978643530,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023171","name":"Life Sciences Research Board","doi-asserted-by":"publisher","award":["DFTM\/07\/3603\/DIAl\u2010CoE"],"award-info":[{"award-number":["DFTM\/07\/3603\/DIAl\u2010CoE"]}],"id":[{"id":"10.13039\/501100023171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023171","name":"Life Sciences Research Board","doi-asserted-by":"publisher","award":["MZU\/EWM\/P\u201008"],"award-info":[{"award-number":["MZU\/EWM\/P\u201008"]}],"id":[{"id":"10.13039\/501100023171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023171","name":"Life Sciences Research Board","doi-asserted-by":"publisher","award":["FBR080305"],"award-info":[{"award-number":["FBR080305"]}],"id":[{"id":"10.13039\/501100023171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The enzyme\u2010mimic activity of a well\u2010defined structurally characterized organometallic complex, [Ir(ppy)\u2082(fcbpy)]PF\u2086(\n                    <jats:bold>1<\/jats:bold>\n                    ; ppy = 2\u2010phenylpyridine; fcbpy = 4\u2010ferrocenyl\u20102,2\u2032\u2010bipyridine), a bimetallic iridium\u2010polypyridyl complex is investigated under light irradiation for the first time. This complex exhibits an extended excited\u2010state lifetime of 592\u00a0ns due to bimetallic synergy, and possess oxidase\u2010mimic activity in the presence of light. Leveraging this light\u2010activated oxidase\u2010mimic activity, a simple colorimetric assay is developed that successfully differentiates cancerous cells from normal cells, based on elevated glutathione (GSH) levels. Moreover, in cell viability studies, treatment with 1.25\u00a0mg\u00a0L\n                    <jats:sup>\u22121<\/jats:sup>\n                    of [Ir(ppy)\u2082(fcbpy)]PF\u2086 resulted in only 32.25% viability in a cancer cell line (A549) compared to the untreated control, highlighting its potent anticancer potential. Importantly, noncancerous cells (BEAS\u20102B) maintain \u224872% viability at up to 10\u00a0mg\u00a0L\n                    <jats:sup>\u22121<\/jats:sup>\n                    of catalyst concentration, indicating selective cytotoxicity toward cancer cells. This study establishes [Ir(ppy)\u2082(fcbpy)]PF\u2086 as a promising candidate for both diagnostic and therapeutic applications in cancer, introducing a novel class of organometallic complexes with significant potential in bioassay development and targeted cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/smll.202501627","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:18:19Z","timestamp":1747628299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Photoresponsive Ferrocene\u2010 Augmented Iridium Polypyridyl Complex as an Oxidase Mimic for Selective Glutathione Sensing: Implications for Cancer Diagnostics and Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Diksha J.","family":"Baruah","sequence":"first","affiliation":[{"name":"Materials Sciences Group, Coal, Energy and Materials Sciences Division CSIR\u2010North East Institute of Science and Technology  Jorhat Assam 785006 India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankumoni","family":"Saikia","sequence":"additional","affiliation":[{"name":"Materials Sciences Group, Coal, Energy and Materials Sciences Division CSIR\u2010North East Institute of Science and Technology  Jorhat Assam 785006 India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiranmoy","family":"Barman","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research  Ghaziabad 201002 India"},{"name":"Centre for Infectious Diseases Biological Sciences and Technology Division CSIR\u2010North East Institute of Science and Technology  Jorhat Assam 785006 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasenjit","family":"Manna","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research  Ghaziabad 201002 India"},{"name":"Centre for Infectious Diseases Biological Sciences and Technology Division CSIR\u2010North East Institute of Science and Technology  Jorhat Assam 785006 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-1545","authenticated-orcid":false,"given":"Biswajit","family":"Saha","sequence":"additional","affiliation":[{"name":"Materials Sciences Group, Coal, Energy and Materials Sciences Division CSIR\u2010North East Institute of Science and Technology  Jorhat Assam 785006 India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manash R.","family":"Das","sequence":"additional","affiliation":[{"name":"Materials Sciences Group, Coal, Energy and Materials Sciences Division CSIR\u2010North East Institute of Science and Technology  Jorhat Assam 785006 India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0301446"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0320611"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836290"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1989.257.4.L163"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/74994"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.489"},{"key":"e_1_2_7_7_1","first-page":"263","volume":"30","author":"An L.","year":"2009","journal-title":"J. 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