{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:26:55Z","timestamp":1790094415767,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52272275"],"award-info":[{"award-number":["52272275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Severe trauma and uncontrolled hemorrhage present significant challenges in achieving hemostasis. Considering the limitations of current hemostatic materials, such as inadequate wet tissue adhesion, prolonged hemostasis time, and insufficient antimicrobial properties, a robust adhesive double cross\u2010linked nano\u2010composite hydrogel powder is developed, consisted of polyacrylic acid (PAA), \u025b\u2010Poly\u2010L\u2010lysine (PLL) and layered double hydroxides (Mg\u2010Al LDH, hereinafter referred to as LDH). The obtained PLL\u2010PAA\/LDH composite hydrogel powder exhibited rapid gelation, strong mechanical properties, and superior wet adhesion. Additionally, it offered excellent biocompatibility and antimicrobial properties. In various injury models involving rats and rabbits, the hemostatic performance of the adhesive PLL\u2010PAA\/LDH hydrogel powder surpassed that of commercially available n\u2010butyl\u20102\u2010cyanoacrylate (NBCA) from 3\u00a0\n                    <jats:sc>m<\/jats:sc>\n                    . Notably, the introduction of LDH enhanced the interfacial toughness of the gel system and significantly improved its adhesive properties, demonstrating remarkable hemostatic efficacy across different injury models. Furthermore, in models of rat skin incisions and full\u2010thickness infected skin wounds, the composite hydrogel powder exhibited superior seamless suturing and repair effects compared to commercial products. Overall, this study aims to elucidate the biomedical potential of PLL\u2010PAA\/LDH composite hydrogel powder for applications in hemostatic sealing, seamless suture prevention of acute bleeding, and wound healing.\n                  <\/jats:p>","DOI":"10.1002\/smll.202501830","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T09:31:06Z","timestamp":1748424666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Nanocomposite Reinforced Powder With Fast Self\u2010gelling and Robust Wet Adhesive Performances for Acute Hemostasis and Wound Repair"],"prefix":"10.1002","volume":"21","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 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