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However, the heterogeneous distribution of these endogenous stimuli across different organs presents a significant challenge to clinical translation. To overcome this limitation, developing SO<jats:sub>2<\/jats:sub> donors that respond to exogenous triggers offers a promising strategy for therapeutic advancement. Herein, an exogenous stimuli\u2010responsive strategy is presented for generating SO<jats:sub>2<\/jats:sub> from a series of amphiphilic block copolymers (<jats:bold>BCPx<\/jats:bold>) under visible light irradiation (427\u00a0nm) in a biological environment, aiming to evaluate their potential for cancer therapy. The coumarin\u2010based, water\u2010soluble polymers form well\u2010defined nanostructures (<jats:bold>BCPxNs<\/jats:bold>) in aqueous media, releasing 70\u201385% of the theoretical SO<jats:sub>2<\/jats:sub> within 4\u00a0h. Moreover, the <jats:bold>BCPxNs<\/jats:bold> nanostructures exhibit self\u2010reporting behavior upon SO<jats:sub>2<\/jats:sub> release. In vitro cellular assays with <jats:bold>BCP2Ns<\/jats:bold> nanostructures demonstrate an enhanced antiproliferative effect in cervical carcinoma HeLa cells under visible light irradiation (427\u00a0nm), with an IC<jats:sub>50<\/jats:sub> value of 0.3\u00a0mg mL<jats:sup>\u22121<\/jats:sup>. Investigations using confocal microscopy and flow cytometry confirm SO<jats:sub>2<\/jats:sub>\u2010induced cell death. Overall, this strategy underscores the potential of light\u2010responsive polymeric SO<jats:sub>2<\/jats:sub> donors with spatiotemporal control for cancer therapy.<\/jats:p>","DOI":"10.1002\/smll.202502727","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T08:21:08Z","timestamp":1744014068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Visible Light\u2010Triggered Precision SO<sub>2<\/sub> Release from Polymeric Nanomedicine for Cancer Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Anushree","family":"Mondal","sequence":"first","affiliation":[{"name":"Polymer Research Centre and Centre for Advanced Functional Materials Department of Chemical Sciences Indian Institute of Science Education and Research Kolkata  Mohanpur Nadia West Bengal 741246 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