{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:37:32Z","timestamp":1784770652084,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Developing versatile photosensitizers capable of selectively\u00a0eliminating pathogens over normal cells is an appealing yet highly challenging task. Herein, a novel strategy by exploiting the cationic and amphiphilic synergistic mechanism is introduced to synthesize four aggregation\u2010induced emission (AIE)\u2010active cationic antibacterial photosensitizers (PSs)\n                    <jats:bold>\n                      TSPy\u2010CH\n                      <jats:sub>3<\/jats:sub>\n                    <\/jats:bold>\n                    ,\n                    <jats:bold>MeO\u2010TSPy\u2010Bu<\/jats:bold>\n                    ,\n                    <jats:bold>MeO\u2010TSPy\u2010Va<\/jats:bold>\n                    and\n                    <jats:bold>\n                      MeO\u2010TSPy\u2010CH\n                      <jats:sub>3<\/jats:sub>\n                    <\/jats:bold>\n                    . The four PSs generated both type I and type II reactive oxygen species (ROS) under white light irradiation. They can quickly stain Staphylococcus aureus (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) in 15\u00a0min, but exhibited different Escherichia coli (\n                    <jats:italic>E.coil<\/jats:italic>\n                    ) affinity and living cell invasiveness. The four PSs caused devastating killing to\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and methicillin\u2010resistant Staphylococcus aureus (MRSA)\u00a0at extremely low drug doses and significantly inhibited biofilm formation of drug\u2010resistant strains by synergistic photocytotoxicity and inherent dark toxicity. Their low antibacterial concentrations and minimal invasiveness toward normal cells\u00a0collectively ensured\u00a0biosafety.\n                    <jats:bold>\n                      MeO\u2010TSPy\u2010CH\n                      <jats:sub>3<\/jats:sub>\n                    <\/jats:bold>\n                    with moderate Clog\n                    <jats:italic>P<\/jats:italic>\n                    value stands out from others by virtues of most reliable biosafety, broad\u2010spectrum bactericidal performance, and excellent biofilm inhibition ability. In vivo studies on bacteria\u2010infected wounds confirmed that\n                    <jats:bold>\n                      MeO\u2010TSPy\u2010CH\n                      <jats:sub>3<\/jats:sub>\n                    <\/jats:bold>\n                    reduced inflammation, promoted angiogenesis, and accelerated wound recovery, achieving\u00a0comparable therapeutic outcomes to vancomycin. This work provides enlightenment for designing novel antibacterial phototherapy agents to overcome\u00a0key limitations such as unpredictable biosafety risk, inadequate antibacterial potency, and poor anti\u2010biofilm performance.\n                  <\/jats:p>","DOI":"10.1002\/smll.202502762","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T03:45:35Z","timestamp":1746503135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elaborately Engineered Aggregation\u2010Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing"],"prefix":"10.1002","volume":"21","author":[{"given":"Zu\u2010Sheng","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Macromolecular Drugs and Large\u2010scale Manufacturing School of Pharmaceutical Sciences Wenzhou Medical 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