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It is extremely difficult to precisely regulate the unsaturated coordination environment of single\u2010atom catalysts due to the thermodynamically unstable structure. Herein, a facile \u201cmicelle\u2010confined oxidative crosslinking and coupled coordination\u201d strategy is proposed to construct a copper single\u2010atom catalyst with an unsaturated Cu\u2010N\n                    <jats:sub>2<\/jats:sub>\n                    coordination structure in a confined silica\u2010carbon framework (Cu SA@MCSN), which demonstrate unique pH\u2010dependent multiple\u2010enzymatic activity (peroxidase (POD)\u2010like activity in an acidic environment with a low\n                    <jats:italic>\n                      K\n                      <jats:sub>m<\/jats:sub>\n                    <\/jats:italic>\n                    of 6.9\u00a0mM and\n                    <jats:italic>\n                      V\n                      <jats:sub>max<\/jats:sub>\n                    <\/jats:italic>\n                    of 6.3\u00a0\u00d7\u00a010\n                    <jats:sup>\u22128<\/jats:sup>\n                    \u00a0M\u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    and superoxide dismutase (SOD)\u2010 and catalase (CAT)\u2010like activity under neutral conditions). Density functional theory calculations also further confirm that the asymmetric Cu\u2010N\n                    <jats:sub>2<\/jats:sub>\n                    sites with edge configurations exhibit a strong adsorption capacity for oxygen\u2010containing intermediates showing a faster reaction rate compared to their saturated coordination structure. More importantly, the metformin (MET)\u2010loaded Cu SA@MCSN demonstrates multi\u2010pathway antibacterial ability in acidic microenvironments and long\u2010term anti\u2010inflammatory effects in neutral microenvironments through the downregulation of pro\u2010inflammatory factors and the up\u2010regulation of anti\u2010inflammatory and tissue regeneration factors on a rat model of methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA)\u2010infected diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/smll.202502896","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:25:31Z","timestamp":1750148731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Highly Efficient and Biocompatible Cupper\u2010Based Single\u2010Atom Nanocatalyst with Unsaturated Coordination Structure for Efficient Diabetic Wound Healing"],"prefix":"10.1002","volume":"21","author":[{"given":"Shiyu","family":"Xu","sequence":"first","affiliation":[{"name":"Low Dimensional Materials Chemistry Laboratory Key Laboratory for Ultrafine Materials of Ministry of Education Frontier Science Center of the Materials Biology and Dynamic Chemistry School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 P. 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