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To overcome these challenges,\n                    <jats:sup>131<\/jats:sup>\n                    I\u2010M@HI, a theranostic nanoparticle was\u00a0engineered that synergizes radiotherapy with chemodynamic therapy (CDT). This platform integrated Mn(III) porphyrin and indocyanine green self\u2010assembled on albumin, enabling dual\u2010mode fluorescence\/MRI\u2010guided imaging, tumor\/sentinel lymph node\u2010targeted accumulation, and hypoxia modulation. The Mn(III) porphyrin catalyzes intratumoral hydrogen peroxide into cytotoxic hydroxyl radicals for CDT while alleviating hypoxia to amplify\n                    <jats:sup>131<\/jats:sup>\n                    I radiotherapy. In subcutaneous tumors,\n                    <jats:sup>131<\/jats:sup>\n                    I\u2010M@HI achieved &gt;85% tumor inhibition by inducing immunogenic cell death, marked by calreticulin exposure and high mobility group box 1 release, and triggered systemic anti\u2010tumor immunity. Strikingly, in a breast cancer metastasis model,\n                    <jats:sup>131<\/jats:sup>\n                    I\u2010M@HI selectively eradicated sentinel lymph node metastases, reducing lung metastatic nodules by &gt;90%, representing a critical advancement for preventing metastatic spread. This work pioneers a multifunctional nanoplatform that not only enhances radiotherapy but also redefines precision metastasis inhibition, offering a transformative strategy for advanced cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.202503117","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T06:09:32Z","timestamp":1747375772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Chemodynamic Therapy Enhanced\n                    <sup>131<\/sup>\n                    I\u2010Radiotherapy for Efficient Inhibition on Cancer Growth and Metastasis"],"prefix":"10.1002","volume":"21","author":[{"given":"Caiting","family":"Deng","sequence":"first","affiliation":[{"name":"Institute of Medical Engineering School of Basic Medical Science Health Science Center Xi'an Jiaotong University  No. 76 Yanta West Road Xi'an Shaanxi 710061 China"},{"name":"School of Public Health 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