{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:48:13Z","timestamp":1781758093472,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2325019"],"award-info":[{"award-number":["T2325019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020758","name":"Science and Technology Innovation Group of Shanxi Province","doi-asserted-by":"publisher","award":["2022XM19"],"award-info":[{"award-number":["2022XM19"]}],"id":[{"id":"10.13039\/501100020758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20243030"],"award-info":[{"award-number":["BK20243030"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunomodulators that can amplify the in situ vaccine effect by regulating radiation\u2010induced immunosuppression have been proven to play a pivotal role in improving the radioimmunotherapeutic efficacy of tumors. Nevertheless, they still face challenges to be addressed for effective tumor radioimmunotherapy, such as poor tumor specificity, rapid clearance from lesions, and potential side effects. Herein, a folate receptors (FRs)\u2010targeting and protein sulfenic acid (PSA)\u2010reactive gold nanosystem FA\u2010dAu\u2010CDR is rationally designed and fabricated in which the toll\u2010like receptor 7\/8 immunoagonists are loaded through amphiphilic \u03b2\u2010cyclodextrin (\u03b2\u2010CD). Taking advantage of the specific covalent reaction between PSA and 1,3\u2010cyclohexanedione (CHD) on the surface of AuNPs, this nanosystem can not only specifically target the tumor to deliver R848 agonist efficiently, but also realize high accumulation and prolonged retention of nanoparticles based on the covalent anchoring. More notably, by combining PD\u2010L1 blockade and radiation therapy, enhanced radioimmunotherapy for both primary and distant colon tumors is achieved in living mice. Therefore, these findings offer a universal and powerful nanoplarform for effective radioimmunotherapy of malignant tumors.<\/jats:p>","DOI":"10.1002\/smll.202503133","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T10:24:34Z","timestamp":1751192674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Engineering TLR7\/8 Agonist\u2010Loaded and Tumor\u2010Anchored Gold Nanosensitizers for Enhanced Radioimmunotherapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Zhengzhong","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine TOR University of Rome Tor Vergata  Roma 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirui","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongsheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxiang","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaju","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-9126","authenticated-orcid":false,"given":"Haibin","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.5964"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04636"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/abc93b"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.101084"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13271"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20243-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.26536"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01102-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines7030100"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.09.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.09.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00774"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S305432"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01462-z"},{"key":"e_1_2_7_15_1","first-page":"127","volume":"35","author":"Courtney C. M.","year":"2022","journal-title":"Life Sci. Space Res."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-6049"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2016.51.3.157"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e16117"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.04.014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14292"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.58"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2872"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13385"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802228"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02279-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202418480"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004784"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05882"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c00114"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00459-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.3_suppl.338"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12657-w"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.11.007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.041"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202417871"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5371"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126539"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0236-8"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207733"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg2239"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22621"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08068"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201908712"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR06440H"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.2c00475"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2017.11.005"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307324"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201903332"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201604894"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202109863"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02206"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202503133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202503133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202503133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:26:28Z","timestamp":1772990788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202503133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":53,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/smll.202503133"],"URL":"https:\/\/doi.org\/10.1002\/smll.202503133","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"2025-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2503133"}}