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Herein, an in\u2010situ forming sprayable hydrogel is designed by integrating multifunctional therapeutic properties. The hydrogel is capable of in situ gelation by rapid cross\u2010linking of tannic acid, Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u00a0ions, and acrylamide, thus forming a stable supramolecular double\u2010network with superior adhesion, self\u2010healing ability, and on\u2010demand removability. Further incorporating Flos Sophorae\u2010derived carbon quantum dots and cactus\u2010derived extracellular vesicles, this hydrogel accelerates wound closure, promotes angiogenesis and hair follicle regeneration in murine acute and burn wound mice, and is associated with macrophage polarization from M1 to M2, reducing inflammation and fibrosis. Moreover, the tannic acid\u2010Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010polyacrylamide supramolecular network has ferroptosis\u2010inhibitory properties, highlighting its potential in preventing oxidative damage in chronic wound healing applications. In addition, photothermal conversion capability and inherent antibacterial properties of hydrogel suggest potential for broader applications such as dry heat sterilization, water disinfection, and thermal management. With its rapid gelation, adaptable mechanical properties, and comprehensive therapeutic effects, this hydrogel offers a promising strategy for advanced wound management and holds potential for broader biomedical applications.\n                  <\/jats:p>","DOI":"10.1002\/smll.202503202","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:41:25Z","timestamp":1752075685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Rapidly Gelling Sprayable Hydrogels Integrating Carbon Quantum Dots and Plant Extracellular Vesicles Enable Multifunctional Wound Care via Photothermal Management, Immunomodulation, and Ferroptosis"],"prefix":"10.1002","volume":"21","author":[{"given":"Huining","family":"Ding","sequence":"first","affiliation":[{"name":"Center for Laboratory Animal Service &amp; Experiments The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine  No. 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