{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:41:46Z","timestamp":1789839706514,"version":"4.0.1"},"reference-count":91,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32572743,32172218"],"award-info":[{"award-number":["32572743,32172218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inspired by the excellent antioxidant and anti\u2010inflammatory effects of fucoxanthin and polyphenols, a pH\/ROS dual\u2010response, dual targeting, and gastric stability fucoxanthin microspheres (SA@CCT@MPN@FX) for the effective mitigation of ulcerative colitis (UC) are developed in present study. Metal\u2010phenolic nanoparticles formed from epigallocatechin gallate (EGCG) and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    are employed as the carrier to encapsulate fucoxanthin, followed by surface coating with chondroitin sulfate modified (5\u2010carboxypentyl) (triphenyl) phosphonium bromide, and finally coated with sodium alginate. Structural characterization confirms the successful encapsulation of fucoxanthin within uniformly dispersed core\u2013shell nanostructures. The dual\u2010responsive release characteristics of fucoxanthin in the targeted nanoparticles are observed at low pH and in the presence of 10\u00a0\u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    <jats:sc>m<\/jats:sc>\n                    hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) at pH7.4. Meanwhile, the fabricated fucoxanthin targeted nanoparticles shows excellent macrophage and mitochondrial targeting abilities, the SA@CCT@MPN@FX microspheres can substantially alleviate UC by downregulating the expression levels of oxidative stress and inflammatory cytokines, repairing intestinal damage, ameliorating the composition and relative abundance of intestinal microbiota and short\u2010chain fatty acids levels through the synergistic antioxidant effects of fucoxanthin and EGCG. This study provides a streamlined strategy for constructing dual\u2010responsive targeted delivery systems as well as highlights the potential of oral hydrophobic bioactive substances for UC intervention.\n                  <\/jats:p>","DOI":"10.1002\/smll.202503476","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:40:11Z","timestamp":1758260411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Orally ROS\/pH Dual\u2010Responsive and Targeted Fucoxanthin Microspheres for the Alleviation of Colon Inflammation"],"prefix":"10.1002","volume":"21","author":[{"given":"Shuifang","family":"Mao","sequence":"first","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Agri\u2010Food Resources and High\u2010Value Utilization Zhejiang Engineering Laboratory of Food Technology and Equipment Zhejiang University  Hangzhou 310058 China"},{"name":"Zhejiang University Zhongyuan Institute  Zhengzhou 450000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Agri\u2010Food Resources and High\u2010Value Utilization Zhejiang Engineering Laboratory of Food Technology and Equipment Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Agri\u2010Food Resources and High\u2010Value Utilization Zhejiang Engineering Laboratory of Food Technology and Equipment Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthawuddhi","family":"Donlao","sequence":"additional","affiliation":[{"name":"Unit of Innovative Food Packaging and Biomaterials School of Agro\u2010Industry Mae Fah Luang University  Chiang Rai 57100 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqian","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Agri\u2010Food Resources and High\u2010Value Utilization Zhejiang Engineering Laboratory of Food Technology and Equipment Zhejiang University  Hangzhou 310058 China"},{"name":"Zhejiang University Zhongyuan Institute  Zhengzhou 450000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5998-5962","authenticated-orcid":false,"given":"Jinhu","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Agri\u2010Food Resources and High\u2010Value Utilization Zhejiang Engineering Laboratory of Food Technology and Equipment Zhejiang University  Hangzhou 310058 China"},{"name":"Zhejiang University\u2010Wuxi Xishan Modern Agriculture Joint Research Center  Wuxi 214117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.06.008"},{"key":"e_1_2_8_2_1","first-page":"559","volume":"73","author":"Ananthakrishnan A. 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