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However, clinical imaging and biopsy techniques suffer the bulky testing equipment and high cost, and blood assay requires blood pretreatment before analysis to significantly restrict home\u2010in self\u2010examination and postoperative follow\u2010up of PCa. Herein, a blood\u2010drop 4\u2010min\u2010test technique is designed to precisely screen PCa by a high\u2010ordered coaxial\u2010nanocables\u2010based aptasensor. The electrospinning potential is employed as the driving force to regulate the distribution of mixed reduced graphene oxide and polyacrylonitrile from disorder to highly order to large\u2010scale weave coaxial nanocables\u2010based films. This architecture has contributed abundant active DNA bonding sites and served as 3D network electron transmission channels to dramatically amplify detection signals with short response time. Moreover, a target\u2010induced chain release strategy is implemented to precisely capture the PCa biomarker. Furthermore, a household PCa analyzer is developed to achieve ultrafast, precise, and nonhospital assays of clinical patients within 4\u00a0min which is 30 times faster than the state\u2010of\u2010the\u2010art commercial instruments. This high\u2010performance analyzer has great potential for early screening and prognostic evaluation of PCa to benefit real\u2010time tests for both in\u2010hospital and nonhospital patients.<\/jats:p>","DOI":"10.1002\/smll.202504714","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:25:31Z","timestamp":1750148731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Coaxial\u2010Nanocables Constructed Flexible Aptasensor for Ultrafast Blood\u2010Drop Detection of Prostate Cancer"],"prefix":"10.1002","volume":"21","author":[{"given":"Xueli","family":"Yuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing 211816 P. R. 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