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However, efficient and selective Type\u2010I reactive oxygen species (ROS) generators remain scarce. Here, Limantrafin (Notch1 transcription inhibitor) conjugated BODIPY photosensitizer is reported that selectively produces superoxide radicals (O\u2082\u2022\u207b) upon green light irradiation and exhibits a significantly higher phototherapeutic index (PI) than its structural analog. Theoretical studies and delayed photoluminescence measurements indicate that efficient intersystem crossing from the singlet excited state (S\u2081) to an intermediate triplet (T\u2082), followed by relaxation to a long\u2010lived triplet state (T\u2081), may facilitate effective electron transfer to molecular oxygen. In triple\u2010negative breast cancer (TNBC) cells (MDA\u2010MB\u2010231), the lead compound shows significantly high PI (&gt;3700) by low\u2010intensity green light irradiation. Furthermore, encapsulation in glycopolymer\u2010based nanoparticles enhances cancer cell selectivity and therapeutic efficacy. Interestingly, there is also a reduction in multiple stemness\u2010associated gene expression and downregulation of Cluster of Differentiation 44 (CD44) and Intercellular Adhesion Molecule 1 (ICAM\u20101\/CD54) surface protein markers that promote stemness and immune evasion in TNBC. This dual action may impair tumor aggressiveness, recurrence, and promote immunogenic cell death. The findings highlight that the conjugation of the Notch1 inhibitor, Limantrafin, with BODIPY widens the horizon of Type\u2010I photosensitizers to design next\u2010generation PDT agents.\n                  <\/jats:p>","DOI":"10.1002\/smll.202505316","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:07:31Z","timestamp":1750648051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Limantrafin\u2010BODIPY Conjugates Reduce Stemness and Metastatic Potential via Superoxide Driven Phototherapy in Triple Negative Breast Cancer"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0487-6598","authenticated-orcid":false,"given":"Shilpendu","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences and Centre for Advanced Functional Materials (CAFM) Indian Institute of Science Education and Research Kolkata Mohanpur Campus  Mohanpur West Bengal 741246 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-0726","authenticated-orcid":false,"given":"Soumya","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Centre for Advanced Functional Materials (CAFM) Indian Institute of Science Education and Research Kolkata Mohanpur Campus  Mohanpur West Bengal 741246 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7512-1503","authenticated-orcid":false,"given":"Sayar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research (IISER) Kolkata Mohanpur Campus  Mohanpur West Bengal 741246 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1700-0293","authenticated-orcid":false,"given":"Sujato","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Centre for Advanced Functional Materials (CAFM) Indian Institute of Science Education and Research Kolkata Mohanpur Campus  Mohanpur West Bengal 741246 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-3395","authenticated-orcid":false,"given":"Priyadarsi","family":"De","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Centre for Advanced Functional Materials (CAFM) Indian Institute of Science Education and Research Kolkata Mohanpur Campus  Mohanpur West Bengal 741246 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research (IISER) Kolkata Mohanpur Campus  Mohanpur West Bengal 741246 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9545-8628","authenticated-orcid":false,"given":"Arindam","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Centre for Advanced Functional Materials (CAFM) Indian Institute of Science Education and Research Kolkata Mohanpur Campus  Mohanpur West Bengal 741246 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805246"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00891"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00381"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00173B"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC01214C"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10288"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110832"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00271D"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00594F"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805138"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012477"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201601902"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05019"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213604"},{"key":"e_1_2_8_17_1","first-page":"1784","volume":"13","author":"Yu W. 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