{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:43:24Z","timestamp":1784699004261,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21705141"],"award-info":[{"award-number":["21705141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fluorescent nanozymes allow the use of both fluorescence and catalytic functions for theragnostic and bioanalytical applications. However, few fluorescent nanozymes with both high fluorescence yield and high catalytic activities are available. CsPbX\n                    <jats:sub>3<\/jats:sub>\n                    perovskite nanocrystals (PNCs) have strong fluorescence but very weak catalytic activities. Here, a microenvironment electron transfer regulation strategy is proposed to enhance the nanozymatic activities and stability of PNCs through the incorporation of Fe metal\u2010organic framework (MOF). By in suit growth of an amphiphilic polymer (octylamine\u2010modified polyacrylic acid) capped PNCs on MOF, the oxidase (OXD)\u2010like activity of PNCs is enhanced sevenfold. X\u2010ray absorption near\u2010edge structure (XANES) and extended X\u2010ray absorption fine structure (EXAFS) characterizations revealed that forming the composition results in valence state shifts of the Fe atoms, indicating an electron transfer from PNCs to MOF enabled by the built\u2010in electric field, which improved the catalytic activities. Moreover, the nanocomposite also displays peroxidase (POD)\u2010like activity, and its dual enzyme\u2010like catalytic mechanism and activities are studied experimentally and theoretically. At last, a nanozyme cascade catalytic system based on the dual mimic enzyme of PNCs@MOF is constructed for ratiometric fluorescence biosensing of ascorbic acid with high sensitivity. This work provides an attractive fluorescent nanozyme, greatly expanding its application in bioanalysis.\n                  <\/jats:p>","DOI":"10.1002\/smll.202505502","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:27:06Z","timestamp":1752233226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An Electron Transfer Regulation Strategy to Enhance the Catalytic Activity of Perovskite Fluorescent Nanozyme by Incorporation of Fe Metal\u2010organic Framework for Biomimetic Cascade Catalysis"],"prefix":"10.1002","volume":"21","author":[{"given":"Long","family":"Chen","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University  Yangzhou 225002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University  Yangzhou 225002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enxian","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University  Yangzhou 225002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University  Yangzhou 225002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University  Yangzhou 225002 P. R. China"},{"name":"Department of Chemistry Waterloo Institute for Nanotechnology University of Waterloo 200 University Avenue West  Waterloo Ontario N2L 3G1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juewen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Waterloo Institute for Nanotechnology University of Waterloo 200 University Avenue West  Waterloo Ontario N2L 3G1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5319-0480","authenticated-orcid":false,"given":"Huan","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University  Yangzhou 225002 P. R. 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