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It is widely recognized as a major risk factor for gastric diseases, and its eradication could effectively treat peptic ulcers and gastritis, and reduce the mortality rate of gastric cancer. However, the antibiotic combination therapies typically used to eradicate\n                    <jats:italic>H. pylori<\/jats:italic>\n                    can disrupt the gut microbiota. Therefore, this study presents a gastrointestinal environment intelligent\u2010responsive nanozyme (CeOSL) for treatment of multidrug\u2010resistant\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infections and regulation of inflammation. The oxidase\u2010like activity of CeOSL is activated in the gastric juice and mucus, which generates superoxide radicals that eradicate\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . Furthermore, CeOSL can scavenge reactive oxygen species to alleviate inflammation in the gastric epithelium with no significant effect on symbiotic microbiota, which addresses the pathological conditions associated with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infections. This pH\u2010modulated nanozyme approach provides a safer and more effective strategy for treatment of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1002\/smll.202505845","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:33:47Z","timestamp":1758195227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal Environment Intelligent\u2010Responsive Nanozyme for the Treatment of Multidrug\u2010Resistant\n                    <i>Helicobacter pylori<\/i>\n                    Infection"],"prefix":"10.1002","volume":"21","author":[{"given":"Ke","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medical Engineering Haojing College of Shaanxi University of Science &amp; Technology  Xianyang Shaanxi 712046 P. R. 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