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In this study, multifunctional piezoelectric nanoplatforms are rationally designed for piezoelectric Fenton\u2010assisted thrombolysis. Piezoelectric hollow barium titanate (hBT) nanoparticles (NPs) are synthesized via template\u2010assisted etching and Fe\u2010doping, followed by fucoidan grafting to obtain hBT\n                    <jats:sub>3Fe<\/jats:sub>\n                    \u2010Fu NPs. The hollow structure demonstrated a four\u2010fold enhancement in piezoelectric response compared to that of solid NPs, and Fe\u2010doping promoted the formation of oxygen vacancies, regulated the bandgap, and enhanced piezoelectric polarization. Moreover, ultrasound\u2010triggered piezoelectrons accelerated Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>2+<\/jats:sup>\n                    transformation, synergistically dissolving thrombi with 88.6% efficiency in vitro. In a venous thrombosis model, fucoidan\u2010mediated active targeting achieved 2.4\u2010fold greater NP accumulation at the thrombus site. Integrated piezoelectric\u2010Fenton therapy resulted in complete thrombus dissolution and vessel recanalization while maintaining &lt; 5% bleeding risk and negligible systemic toxicity. The engineered hBT\n                    <jats:sub>3Fe<\/jats:sub>\n                    \u2010Fu nanoplatform represents a promising non\u2010pharmacological strategy for safe and effective piezocatalytic thrombolytic therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.202505940","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:27:26Z","timestamp":1760009246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrasound\u2010Activated Fe\u2010Doped Hollow BaTiO\n                    <sub>3<\/sub>\n                    Nanoparticles for Targeted Venous Thrombolysis Via Piezo\u2010Amplified Fenton Catalysis"],"prefix":"10.1002","volume":"21","author":[{"given":"Mingbo","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound West China Hospital Sichuan University  Chengdu 610041 P. R. 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