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However, the application of a wide variety of metal\u2013organic frameworks (MOFs) as nanohesives remains seldom reported. Here, the synthesis of 2D calcium\u2010based MOF (Ca\u2010MOF) nanoplates is reported via a simple one\u2010pot approach at room temperature. Rapid, robust, and reversible adhesion between two hydrogels can be achieved by the Ca\u2010MOF nanoplate suspensions. During the adhesion process, interfacial ethanol and TEA are absorbed by the hydrogel through its swelling, forming a Ca\u2010MOF nanoplate multilayer at the interface, which contributes to strong cohesion. Meanwhile, polymer strands adsorbed onto the surface of the Ca\u2010MOF nanoplates and penetrated into the MOF interior, thereby enhancing the interfacial adhesion. Moreover, by adjusting synthesis conditions, including the type of calcium source, calcium ion to terephthalic acid (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/BDC) ratio, and TEA concentration, the morphology of Ca\u2010MOF nanostructures is easily controlled, enabling modulation of the material's adhesive properties. Additionally, biological tissues such as porcine skin can also be glued using Ca\u2010MOF nanoplate suspensions. This strategy represents a rapid, straightforward, and efficient approach for the adhesion of gels or tissues, paving the way for innovative nanodhesive designs.\n                  <\/jats:p>","DOI":"10.1002\/smll.202506795","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T09:59:38Z","timestamp":1755943178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rapid and Tough Hydrogel Adhesion Enabled by Calcium\u2010Based Metal\u2010Organic\u2010Framework Nanoplates"],"prefix":"10.1002","volume":"21","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou 450001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Zhengzhou University  Zhengzhou 450001 P. R. 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