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Developing innovative antimicrobial strategies capable of simultaneously achieving bacterial eradication, inflammation resolution, and tissue regeneration has become imperative. Herein, a nanocomposite featuring plasma\u2010enhanced enzymatic activity and immunoregulatory properties is engineered, designed to reprogram the wound microenvironment and expedite healing in drug\u2010resistant bacterial infections. Capitalizing on the localized surface plasmon resonance effect of Au@Ag nanoparticles coupled with the pH\u2010dependent peroxidase\u2010like (POD\u2010like) activity of cerium dioxide (CeO\n                    <jats:sub>2<\/jats:sub>\n                    ), the BSA\u2010(Au@Ag\/CeO\n                    <jats:sub>2<\/jats:sub>\n                    ) nanocomposites orchestrate dual\u2010modality photothermal\u2010chemodynamic therapy for enhanced bactericidal efficacy and biofilm disruption. Upon near\u2010infrared laser irradiation, plasmon\u2010generated hot electrons are transferred to CeO\n                    <jats:sub>2<\/jats:sub>\n                    , triggering massive reactive oxygen species production via enhanced POD\u2010like catalysis. This synergistic dual\u2010action mechanism eradicates methicillin\u2010resistant Staphylococcus aureus (MRSA) through membrane disruption and reactive oxygen species (ROS)\u2010induced oxidative stress. Remarkably, the nanosystem not only suppresses proinflammatory cytokine storms but also steers macrophage polarization toward tissue reparative M2 phenotypes at infection sites, thereby alleviating pathological inflammation and fostering regenerative microenvironments. Biosafety assessments confirm the absence of discernible toxicity in vital organs. This multifunctional platform represents a paradigm\u2010shifting strategy for managing antibiotic\u2010resistant wound infections, providing a clinically translatable solution to combat antimicrobial resistance.\n                  <\/jats:p>","DOI":"10.1002\/smll.202507586","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T12:39:28Z","timestamp":1755088768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Light\u2010Activatable Nanotherapeutic Platform Synchronizing ROS\u2010Mediated Antibacterial Action with Macrophage Polarization for Refractory Wound Infections"],"prefix":"10.1002","volume":"21","author":[{"given":"Xinyue","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. 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