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Nanocarriers hold transformative potential for treating these conditions, yet corneal epithelium impermeability necessitates intraocular injection. Given the discomfort and infection risk, an injectable hydrogel\u2010based depot offers a promising strategy for sustained delivery. However, because the aqueous humor is a large, fluid\u2010filled environment, achieving spatially confined gelation remains a key challenge, as injected materials rapidly diffuse. Herein, a composite hydrogel (C\u2010gel) is presented that enables localized in situ gelation and sustained nanocarrier release within the anterior chamber. This is achieved by embedding poly(ethylene glycol)\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010poly(propylene sulfide) (PEG\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010PPS) filomicelles (FMs) within a crosslinked multi\u2010arm PEG hydrogel. The FM structure facilitated the spatial confinement of DBCO\u2010 and azide\u2010PEG crosslinking reactions, promoting efficient gel formation\u2014the first use of FM morphology for enhanced localized gelation. As a result, 90% of the injected polymer is retained within the crosslinked matrix. Embedded FMs undergo oxidation\u2010induced cylinder\u2010to\u2010sphere transitions, facilitating gradual release of micellar nanocarriers. The mechanical properties and release kinetics of C\u2010gels can be specified by adjusting the\u00a0formulation parameters. Sustained release of dye\u2010loaded\u00a0nanocarriers, used as a fluorescent model cargo, persisted for over a month under anterior chamber\u2013mimicking conditions, underscoring the C\u2010gel's potential as a long\u2010acting depot for ocular drug delivery.\n                  <\/jats:p>","DOI":"10.1002\/smll.202508236","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T20:16:44Z","timestamp":1766002604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Filomicelle\u2010Embedded Composite Hydrogels for Localized Gelation Within the Anterior Chamber of the Eye"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9122-3901","authenticated-orcid":false,"given":"Hyeohn","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Northwestern University Evanston 60208 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