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Nevertheless, devising durable COF membranes with fine nanochannels for high\u2010efficiency separation remains challenging. Here, a triangular\u2010topology COF membrane is reported with subnanometer pores through designing a six\u2010fold symmetric hexa(4\u2010formylphenyl)benzene as a building block. A dense COF membrane is interfacially synthesized through the sustained diffusion and reaction of hydrazine from porous substrates under catalysis. Thus\u2010synthesized membrane features an ultrathin thickness of 54\u00a0nm, high\u2010density nanochannels, and high solvent affinity. The membrane yielded exceptional solvent permeances (24.9 L m\n                    <jats:sup>\u22121<\/jats:sup>\n                    h\n                    <jats:sup>\u22121<\/jats:sup>\n                    bar\n                    <jats:sup>\u22121<\/jats:sup>\n                    for methanol) and sharp molecular rejection curves with low molecular weight cut\u2010offs of 380\u00a0Da, outperforming congeneric OSN membranes. This further translated into an excellent separation capability toward mixed antitumor pharmaceuticals within organic solvents, despite under high concentration and prolonged operation. This skillful design drives COF membranes as a promising candidate for reforming separation processes of high\u2010value pharmaceuticals in industries.\n                  <\/jats:p>","DOI":"10.1002\/smll.202508272","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:48:21Z","timestamp":1758703701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrathin Subnanoporous Covalent Organic Framework Membranes with Triangular Topologies for Efficient Pharmaceutical Separation"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1103-7306","authenticated-orcid":false,"given":"Hukang","family":"Guo","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou 310058 P. R. 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