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Oxidative stress and inflammation are central pathogenic mechanisms of DOX\u2010induced cardiomyopathy (DIC), characterized by extensive innate immune cells infiltration into the injured myocardium. The immune landscape of DIC mouse models is systematically characterized, identifying macrophages as the predominant immune subset. Based on this, a hybrid nanozyme (PB@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs) is developed, comprising Prussian blue nanoparticles (PB NPs) and cerium oxide nanoparticles (CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs). The PB NPs core provides magnetic resonance imaging (MRI) contrast, while CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs surface modification enhances immune cell uptake, promotes retention in inflamed cardiac tissue, and augments reactive oxygen species (ROS) scavenging and anti\u2010inflammatory efficacy. In vitro experiments demonstrate that PB@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs alleviate mitochondrial damage, inhibit apoptosis, and induce macrophage M2 polarization. In vivo studies show that PB@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs facilitate myocardial accumulation, reduce cardiac inflammation and fibrosis, and improve cardiac function. By integrating the antioxidative and anti\u2010inflammatory effects of PB@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs with inflammation\u2010mediated immune cell retention in injured myocardium, this study presents a promising nanotherapeutic platform for targeted and precise intervention in anthracycline\u2010induced cardiotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/smll.202508419","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T15:37:27Z","timestamp":1761147447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerium Oxide Doped Prussian Blue Nanoparticles for Targeted Modulation of the Myocardial Injury Microenvironment and Theranostics of Doxorubicin\u2010Induced Cardiomyopathy"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-8745","authenticated-orcid":false,"given":"Zhi\u2010Nan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing 100142 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing 100142 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Hu","sequence":"additional","affiliation":[{"name":"Senior Department of General Surgery the First Medical Center of Chinese PLA General Hospital  No.28 Fu Xing Road, Hai Dian District Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital Sichuan University  Chengdu 614001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing 100142 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin\u2032en","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai 200127 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-1910","authenticated-orcid":false,"given":"Ying\u2010Shi","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing 100142 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21340"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120463"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2023.101205"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179546819866445"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-022823-035521"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeac106"},{"key":"e_1_2_8_7_1","first-page":"68","volume":"1","author":"Macedo A. 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