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Photothermal immunotherapy addresses this problem by triggering immunogenic cell death (ICD) through photothermal treatment, releasing endogenous immunogenic neoantigens. Herein, guided by the \u201cmulti\u2010rotor &amp; multi\u2010conjugation\u201d concept, near\u2010infrared region II (NIR\u2010II) cyanine molecules are designed with varying numbers of benzene rotors. TPE\u2010CyA, with more benzene rotors, features an ultra\u2010high molar extinction coefficient (1.786 \u00d7 10\n                    <jats:sup>5<\/jats:sup>\n                    <jats:sc>m<\/jats:sc>\n                    <jats:sup>\u22121<\/jats:sup>\n                    cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), a well\u2010balanced fluorescence quantum yield (0.99%), and a 45.72% photothermal conversion efficiency. TPE\u2010CyA nanoparticles (TPE\u2010CyA NPs) are ideal for high\u2010resolution NIR\u2010II fluorescence imaging and angiography. Imaging\u2010guided TPE\u2010CyA NPs show great potential in NIR\u2010II photothermal immunotherapy by effectively suppressing bilateral tumor growth and liver metastasis without additional immunoadjuvants. Moreover, the photothermal immunotherapy guided by TPE\u2010CyA NPs can induce ICD, promote dendritic cell (DCs) maturation, increase T\u2010cell infiltration in tumors, and activate systemic immunity to prevent metastasis and recurrence. This research highlights the potential of NIR\u2010II photothermal therapy in tumor cell ablation, immune activation for cancer and vascular diagnostics, presenting a novel strategy for both primary and metastatic cancers.\n                  <\/jats:p>","DOI":"10.1002\/smll.202508447","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T11:07:09Z","timestamp":1755774429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integration of Multi\u2010Rotor and Multi\u2010Conjugation: Ultrahigh Absorption Coefficient Dye Enables NIR\u2010II Fluorescence Imaging\u2010guided Photothermal Immunotherapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Guining","family":"Cao","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou Guangdong 510060 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