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Here, we present a microfluidic\u2013microelectronic device, the Microfluidic Dielectrophoretic Arresting System (MiDAS) that employs dielectrophoresis (DEP) for high\u2010throughput single\u2010cell and droplet trapping in a compact array. We tested multiple trap geometries, including a 20\u00a0\u00b5m\u2010diameter DEP trap for polymer microbeads, fungal and mammalian cells, and a 40\u00a0\u00b5m\u2010diameter trap for water\u2010in\u2010oil droplets. The platform demonstrates broad sample compatibility, reliably immobilizing cells and beads of varying sizes. By integrating optical imaging and Raman spectroscopy, we enable interrogation of individual cells with temporal resolution. We describe different modes of MiDAS operation to trap and manipulate single\u2010cells or reverse emulsion droplets on demand, with applications in droplet microfluidics. Our MiDAS platform's simple fabrication, robust performance, and broad compatibility with diverse sample types position it as a versatile tool with transformative potential for single\u2010cell analysis, offering researchers an innovative approach to interrogate cellular dynamics with precision and throughput.<\/jats:p>","DOI":"10.1002\/smll.202508692","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:45:42Z","timestamp":1776336342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Capture, Confine, Characterize: High\u2010Throughput Dielectrophoresis\u2010Based Single\u2010Cell Microfluidics Platform to Analyze Mammalian and Yeast Cells Using Raman Spectroscopy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-7511","authenticated-orcid":false,"given":"Bum\u2010Joon","family":"Jung","sequence":"first","affiliation":[{"name":"Section 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