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This study introduces an innovative approach that utilizes engineered\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    to bioconjugate and assemble the pre\u2010erythrocytic circumsporozoite protein\u2010derived RTS,S antigen and the sexual\u2010stage Pfs47 subdomain into biopolymer particles (BPs), generating the dual\u2010antigen Pfs47\u2010RTS,S\u2010BP vaccine. Compared to single\u2010antigen BPs, the fused Pfs47\u2010RTS,S\u2010BP formulation shows synergistic enhancement in immunogenicity and protective efficacy. Pfs47\u2011RTS,S\u2011BP retains its physical properties and antigenicity after storage at 37\u00b0C. Although functional in vivo assessment of these thermostable formulations has not yet been performed, the findings indicate promising thermostability that could help overcome cold\u2011chain limitations in malaria\u2011endemic regions. Pfs47\u2010RTS,S\u2010BP induces durable antibody and T cell responses alongside crucial liver\u2010resident memory T cells for frontline defence. Vaccine\u2010induced antibodies efficiently neutralize sporozoites and inhibit parasite transmission. Pfs47\u2010RTS,S\u2010BP generates RTS,S\u2010specific antibody levels 5.3\u2010fold higher than the protective thresholds of the current RTS,S\/AS01 vaccine. The Pfs47\u2010RTS,S\u2010BP formulation also achieves 80.4% protection against mosquito bite challenge and 68.15% transmission\u2010reducing activity, demonstrating strong potential as a robust, dual\u2010stage malaria vaccine candidate. Overall, this work underscores the potential of Pfs47\u2011RTS, S\u2011BP to overcome key limitations of current vaccines and to substantially advance global malaria control efforts.\n                  <\/jats:p>","DOI":"10.1002\/smll.202508762","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:42:00Z","timestamp":1774341720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission"],"prefix":"10.1002","volume":"22","author":[{"given":"Nivethika","family":"Sivakumaran","sequence":"first","affiliation":[{"name":"Centre For Cell Factories and Biopolymers Institute For Biomedicine and Glycomics Griffith University  Nathan Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevel","family":"Flores\u2010Garcia","sequence":"additional","affiliation":[{"name":"W. 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