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Conventional systemic therapies, typically administered orally or by injection, often result in gastrointestinal side effects and poor patient compliance. Although microneedles (MN) enable localized and minimally invasive drug delivery through the skin, their therapeutic efficacy remains limited by uncontrollable and unpredictable release kinetics. Here, this work reports a wearable electro\u2010controlled MN device (EMND) for synergistic RA therapy. The EMND mainly consists of a MN array, a conductive hydrogel, a miniature control circuit and a smartphone\u2010based application. The MN array facilitates transdermal access at the lesion site, while the conductive hydrogel enables electrically triggered, on\u2010demand drug release via iontophoresis. This design allows precise spatiotemporal control of multiple therapeutics to achieve synergistic anti\u2010inflammatory and analgesic effects. In RA rat models, EMND treatment reduced inflammatory cytokine levels to 11.38%\u201314.51% of baseline and increased pain thresholds by 5.24\u2010fold. Overall, this wearable EMND offers an exciting prospect for facilitating RA treatments and autonomy of therapeutic interventions, with potential applications for other chronic conditions.<\/jats:p>","DOI":"10.1002\/smll.202508880","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:46:28Z","timestamp":1764157588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Wearable Electro\u2010Controlled Microneedle Device for Synergistic Rheumatoid Arthritis Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Shuijin","family":"Chen","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen 518107 China"},{"name":"Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen 518107 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gong","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen 518107 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen 518107 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