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Photothermal therapy (PTT), a minimally invasive modality, employs photothermal agents (PTAs) to convert light into localized heat, thereby elevating the local temperature of tumor tissues to induce hyperthermia\u2010mediated cell death. Aggregation\u2010induced emission luminogens (AIEgens) with second near\u2010infrared (NIR\u2010II) emission have garnered increasing attention owing to their high photothermal conversion efficiency, excellent photostability, and capabilities for real\u2010time fluorescence imaging. These properties render NIR\u2010II AIEgens particularly attractive for applications in bioimaging, targeted drug delivery, and integrated theranostics. This review outlines recent advances in the molecular engineering of NIR\u2010II AIEgens aimed at improving photothermal performance and evaluates delivery platforms designed to facilitate tumor\u2010specific accumulation. Preclinical investigations encompassing diverse tumor models\u2014including breast, colorectal, brain, pancreatic, and hepatic malignancies\u2014are systematically assessed with reference to clinically relevant metrics. 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