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It is shown that high transverse relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    ) can be obtained by clustering hydrophobic SPIONs with an average core diameter of \u22487\u00a0nm via self\u2010assembly with amphiphilic polyethylene glycol\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010poly(\n                    <jats:italic>L<\/jats:italic>\n                    \u2010Leucine) block copolymers, PEG\n                    <jats:sub>n<\/jats:sub>\n                    \u2010\n                    <jats:italic>b\u2010<\/jats:italic>\n                    p(\n                    <jats:italic>L<\/jats:italic>\n                    \u2010Leu)\n                    <jats:sub>m<\/jats:sub>\n                    , where the PEG chains are terminated by methoxy (CH\n                    <jats:sub>3<\/jats:sub>\n                    O\u2010PEG\n                    <jats:sub>n<\/jats:sub>\n                    ) or hydroxyl groups (HO\u2010PEG\n                    <jats:sub>n<\/jats:sub>\n                    ). Clusters ranging from 65 to 85\u00a0nm in diameter are formed by polymer coating and stabilization of hydrophobic SPION aggregates and yield high\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    values ranging from 226 to 342 s\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0m\n                    <jats:sc>m<\/jats:sc>\n                    Fe\n                    <jats:sup>\u22121<\/jats:sup>\n                    with negligible longitudinal relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    ) and high saturation magnetization near that of bulk maghemite. Polymer composition determines the critical micelle concentrations, notably the length of the hydrophobic segment, and the extent of hydrophobic drug loading. However, it does not significantly impact the size of the SPION cluster assemblies, their magnetic relaxivity, or their drug release, whether passive or during pulsed, intermittent magnetic stimulation. This work demonstrates that the self\u2010assembled amphiphilic block copolymer\u2010based micelles can be used to enhance the colloidal and magnetic relaxivity behavior of SPION clusters while providing variable drug loading and the opportunity for end\u2010group functionalization.\n                  <\/jats:p>","DOI":"10.1002\/smll.202509099","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T19:22:00Z","timestamp":1760901720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multicore SPION Clustering within Poly(amino acid) Corrals for Enhanced MRI Contrast and Drug Release"],"prefix":"10.1002","volume":"21","author":[{"given":"Mohamed F.","family":"Kabil","sequence":"first","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences University of Rhode Island 7 Greenhouse Road Kingston RI 02881 United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adekunle Titus","family":"Akinmola","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alabama in Huntsville  301 Sparkman Drive Huntsville AL 35899 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Chemical Biomolecular and Materials Engineering University of Rhode Island  3 East Alumni Avenue Kingston RI 02881 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzahidul I.","family":"Anik","sequence":"additional","affiliation":[{"name":"Department of Chemical Biomolecular and Materials Engineering University of Rhode Island  3 East Alumni Avenue Kingston RI 02881 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alabama in Huntsville  301 Sparkman Drive Huntsville AL 35899 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Scholz","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alabama in Huntsville  301 Sparkman Drive Huntsville AL 35899 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Robert J. &amp; Nancy D. 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