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To overcome this limitation, a versatile nanoplatform constructed from amphiphilic polymers containing densely packed long alkyl chains that create stable hydrophobic gas reservoirs is developed. These nanostructures demonstrate unprecedented H\n                    <jats:sub>2<\/jats:sub>\n                    S retention capabilities (&gt;70% after 4 weeks at 4\u00a0\u00b0C), surpassing the stability limitations of current delivery systems. The integration of ultrasound responsiveness allows spatiotemporal regulation of nanoparticle migration and gas release via three key mechanisms: 1) Intensity\u2010dependent acoustic radiation forces enhance renal accumulation by 1.5\u2010fold; 2) Facilitated transendothelial transport enables delivery to proximal tubular epithelial cells within 2\u00a0h; and 3) Sustained intratubular retention (&gt;8\u00a0h) maintains therapeutic H\n                    <jats:sub>2<\/jats:sub>\n                    S levels. In cisplatin\u2010induced nephrotoxicity models, ultrasound\u2010activated H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010loaded nanoparticles showed superior therapeutic efficacy, reducing tubular injury by more than 45% and accelerating functional recovery compared to conventional H\n                    <jats:sub>2<\/jats:sub>\n                    S donors. This approach eliminates the need for bypassing complex donor chemistry while providing precise external control over gas release, offering a transformative strategy for gaseous nanomedicine.\n                  <\/jats:p>","DOI":"10.1002\/smll.202509186","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T19:10:29Z","timestamp":1763579429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Manipulated Nanoplatform with Stable Hydrophobic Reservoirs for Spatiotemporal Controlled Renal Delivery of Therapeutic Gases"],"prefix":"10.1002","volume":"22","author":[{"given":"Tiandong","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical Engineering Southeast University  Nanjing 211189 P. R. 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