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Particularly for soft hydrogel in printing central nervous tissues, it is essential to ensure cell viability and differentiation with customized architecture. This study introduces a nanoengineered chitosan micelle\u2010crosslinked hydrogel (CDP) system, achieving three distinct rheological properties by regulating the relative contribution of dynamic covalent crosslinking vs. micelle stacking through high shear\u2010induced crystallization to the final printing performance. The optimized CDP\u2010II bioink exhibits balanced shear strain tolerance and stability within 200% strain. Rheo\u2010SAXS analysis reveals the reversible lyotropic liquid crystal (LLC) structures, while SANS fitting identifies the radius (8.1\u00a0nm) and packing ratio (36%) for the micelles. The CDP\u2010II bioink with 0.6\u00a0kPa shear modulus demonstrates proper mechanical properties and biocompatibility for neural stem cells. The bioink supports the differentiation of neural stem cells while protecting cell death from extrusion. The brain slice\u2010like tissue patch printed from the CDP\u2010II bioink can be picked up, manipulated, and moved to the culture vessel, underscoring its potential in neural tissue engineering. The structure\u2010property relationship established through the model system can be used in the precise structure design of a binary hydrogel for bioprinting.<\/jats:p>","DOI":"10.1002\/smll.202509654","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:06:13Z","timestamp":1777021573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanoengineered Micellar Hydrogel with Controllable Strain\u2010Dependent Behavior for Brain Slice\u2010Like Tissue Patch Bioprinting"],"prefix":"10.1002","volume":"22","author":[{"given":"Shih\u2010Ho","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Polymer Science and Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Polymer Science and Engineering National Taiwan 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