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High\u2010performance X\u2010ray scintillators require high luminous efficiency and excellent contrast enhancement. Circularly polarized luminescence (CPL) materials effectively suppress crosstalk and enhance image contrast. Herein, a novel hexanuclear chiral gold cluster (\n                    <jats:bold>Cluster\u2010ETH<\/jats:bold>\n                    ) with steroidal ethisterone frameworks is presented. The rigidity\u2010engineered AIE cluster achieves high quantum yield (84.9%) and an intense CPL signal with a g\n                    <jats:sub>lum<\/jats:sub>\n                    value of \u22125.3 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    in the aggregated state. Crystal analysis and TD\u2010DFT calculations show that helical packing via hydrogen bonding interactions and aurophilic interactions drives efficient triplet harvesting.\n                    <jats:bold>Cluster\u2010ETH<\/jats:bold>\n                    enables the first chiral gold cluster scintillator for X\u2010ray imaging, demonstrating a low\u2010detection\u2010limit (118 nGy s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ).\n                    <jats:bold>Cluster\u2010ETH<\/jats:bold>\n                    establishes the novel application of chiral gold clusters in advanced imaging technologies, providing a paradigm for the development of efficient X\u2010ray scintillators.\n                  <\/jats:p>","DOI":"10.1002\/smll.202509741","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:23:39Z","timestamp":1760610219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Boosting X\u2010Ray Imaging with a Highly Emissive Steroidal Gold Cluster Featuring Aggregation\u2010Induced Circularly Polarized Luminescence"],"prefix":"10.1002","volume":"21","author":[{"given":"Xiao\u2010Yan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide College of Chemistry Central China Normal University  Wuhan 430079 China"},{"name":"College of Chemical Engineering Shijiazhuang University  Shijiazhuang 050035 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Wang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical Sciences Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster Materials Green Catalysis Center, and College of Chemistry Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debin","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide College of Chemistry Central China Normal University  Wuhan 430079 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Gong","sequence":"additional","affiliation":[{"name":"Shenzhen MSU\u2010BIT University  Shenzhen 518172 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-6418","authenticated-orcid":false,"given":"Sheng Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide College of Chemistry Central China Normal University  Wuhan 430079 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c00563"},{"key":"e_1_2_7_2_1","first-page":"03","volume":"37","author":"Wang J. 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