{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:59:02Z","timestamp":1793872742381,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M682225"],"award-info":[{"award-number":["2020M682225"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22371172"],"award-info":[{"award-number":["22371172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Effective antithrombotic therapy requires rapid removal of obstructive thrombi to restore blood flow, and nanotechnology offers a promising solution. However, conventional passive nanomaterials face limitations such as poor biodistribution and weak targeting efficiency. To address these challenges, a dual\u2010driven Janus nanomotor is developed consisting of a covalent organic framework (COF) core, a platinum shell, and a platelet membrane coating, which combines multiple therapeutic functions. The porous COF structure enables heparin loading and controlled release while exhibiting intrinsic photothermal properties. The platinum shell acts as a catalase mimic and exhibits surface plasmon resonance, allowing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition and near\u2010infrared light\u2010enhanced photothermal thrombolysis. The platelet membrane coating enhances thrombus\u2010targeting capability. This nanomotor integrates reactive oxygen species scavenging, efficient photothermal thrombolysis, and anti\u2010recurrence effects, demonstrating strong thrombolytic efficacy and anticoagulant effects in both the in vitro thrombosis model and the mouse blacktail model. The study demonstrates the potential of COFs as multifunctional nanoplatforms for thrombus therapy, highlighting their structural advantages\u2014including high porosity, tunability, biocompatibility, and inherent photothermal activity\u2014to advance vascular nanomedicine.\n                  <\/jats:p>","DOI":"10.1002\/smll.202509853","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:33:13Z","timestamp":1763130793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Covalent Organic Framework\u2010Based Nanomotor for Thrombus Therapy"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1827-5577","authenticated-orcid":false,"given":"Jie","family":"Feng","sequence":"first","affiliation":[{"name":"College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University  Jinan 250014 P. 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