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The system utilizes an iron\u2010doped mesoporous silica framework co\u2010loaded with photothermal converter Y6 and hydrophobic precursors (o\u2010phenylenediamine\/benzil), surface\u2010coated with high\u2010M\n                    <jats:sub>W<\/jats:sub>\n                    PEG as a stimuli\u2010responsive gatekeeper. Upon 808\u00a0nm NIR laser irradiation, Y6\u2010mediated photothermal heating induces PEG phase transition, creating a transient solvent microenvironment that enables in situ synthesis of the cytotoxic agent 2,3\u2010diphenylquinoxaline (2,3\u2010DPQ) selectively within tumors. Concurrently, the nanoplatform degrades to release Fe\n                    <jats:sup>2+<\/jats:sup>\n                    ions, inducing synergistic ferroptosis alongside drug synthesis. In vitro and in vivo studies demonstrate excellent biocompatibility and precise spatiotemporal control of therapeutic activation. By integrating rapid, localized drug generation with slow\u2010hydrolysis\u2010mediated ferroptosis, this dual\u2010temporal strategy expands the applicability of hydrophobic compounds and organic chemistry for precision nanomedicine.\n                  <\/jats:p>","DOI":"10.1002\/smll.202509856","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:22:57Z","timestamp":1773051777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photothermally Triggered Intratumoral In Situ Drug Synthesis: A Smart Nanoplatform for NIR\u2010Controlled Precise Activation of Antitumor Precursors"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhonghui","family":"Ma","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 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