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The heterogeneous spatiotemporal progression of multifocal breast cancer at the microscale plays an infamous role in phenotype variation and malignant degree increase. However, prenatal bisphenol exposure\u2010induced heterogeneous features of offspring during breast cancer progression are far from elucidated. Using a noninvasive ultrasound elastography (UE) guided\u2010spatiotemporal metabolomics strategy, the study obtains the BPS\u2010treated comprehensive fingerprints and characteristic crosstalk of tumors at the microscale by integrating elasticity\u2010histopathology\u2010metabolism in multifocal tumorigenesis across the entire progression of breast cancer and also evaluates the degrees of malignancy and metastasis. Prenatal exposure to BPS (10 \u00b5g\/kg bw\/day) significantly shortens the breast tumor latency of female offspring in multiple primary foci and accelerates the lung metastasis using a spontaneous transgenic model of breast cancer. Prenatal BPS exposure changes the intra\u2010 and inter\u2010tumor heterogeneity in histopathological characteristics and induces the spatial dyshomeostasis of lipid metabolism by enlarging the micro\u2010area of neoplasm and necrosis, also promoting the infiltration of inflammation cells in lung metastasis. 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