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Here, a minimalist, self\u2010calibrating ratiometric probe based on homologous Ag\n                    <jats:sub>2<\/jats:sub>\n                    Se quantum dots (QDs) is developed. Through rational redesign of tributylphosphine\u2010mediated coordination kinetics, continuous size\u2010dependent emission tuning across 935\u20131710\u00a0nm, with the synthetic mechanism and structure\u2013property relationships systematically elucidated, is achieved. The inherently low\u2010toxicity Ag\n                    <jats:sub>2<\/jats:sub>\n                    Se core, combined with poly(amino acid) coating, ensures excellent biosafety, as validated by in vitro cytotoxicity and in vivo biochemical assays. Two spectrally distinct QDs (emitting at 1040 and 1305\u00a0nm, with full width at half maximum of 176 and 119\u00a0nm) enable multiplexed anatomical imaging, allowing both real\u2010time intraoperative detection and postoperative assessment of MLNs, with a diagnostic threshold ratio of \u22480.9. This work presents a scalable strategy for full\u2010NIR\u2010II monochromatic QD synthesis and establishes a minimal\u2010component biocompatible platform for precision ratiometric diagnostics.\n                  <\/jats:p>","DOI":"10.1002\/smll.202510056","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:30:18Z","timestamp":1761658218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Self\u2010Calibrated Identification of Metastatic Lymph Nodes Using Full\u2010NIR\u2010II Tunable Ag\n                    <sub>2<\/sub>\n                    Se Quantum Dots Engineered by Short\u2010Chain Phosphines"],"prefix":"10.1002","volume":"21","author":[{"given":"Wei","family":"Ge","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200240 P. R. 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