{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:50:45Z","timestamp":1791985845245,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by oxidative stress, impaired antioxidant defense, and gut microbiota dysbiosis. Despite advances in treatment, current therapies remain limited by insufficient efficacy and systemic side effects. Here, we developed a multifunctional nanoplatform (BG\/SOD@ZIF\u2010zc) by encapsulating superoxide dismutase (SOD) within Cu\u2010doped ZIF\u2010zc and coating it with bacterial ghosts for targeted delivery. This system preserved enzymatic activity under gastrointestinal conditions, scavenged reactive oxygen species, and optimized the relative composition of gut microbiota. In zebrafish models, BG\/SOD@ZIF\u2010zc alleviated intestinal inflammation, restored antioxidant enzyme activity, reduced lipid peroxidation, and improved anxiety\u2010like behavior. These findings highlight a dual\u2010action strategy integrating antioxidant reinforcement and microbiota regulation, offering a promising therapeutic avenue for IBD.<\/jats:p>","DOI":"10.1002\/smll.202510165","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:47:28Z","timestamp":1773028048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Engineered Nanoplatform with Dual Anti\u2010Inflammatory and Microbiota\u2010Modulating Actions for Targeted Therapy in Chronic Inflammatory Bowel Disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0859-7011","authenticated-orcid":false,"given":"Yimeng","family":"Fang","sequence":"first","affiliation":[{"name":"Institute of Life Sciences &amp; Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou University  Wenzhou P. R. 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