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Additionally, therapeutic strategies are expanding to include metabolic pathways to trigger apoptosis and reduce tumor growth, especially in cases resistant to conventional chemotherapy. Here, we have created nanocarriers with hybrid\u2010biomimetic coatings that, upon ultrasound activation, release encapsulated copper\u2010based metal\u2010organic frameworks (MOFs) and COP1 gene knockout Cas9 ribonucleoproteins (RNPs). This hybrid\u2010membrane coating, which combines tumor and immune cell membranes with perfluorocarbons, enhances tumor\u2010to\u2010normal cell uptake and allows for controlled release and cytolytic entry of the nanocarrier contents. We observe that the RNPs efficiently knockout the COP1 gene, thereby arresting the cancer cell cycle in the G0\/G1 phase and promoting mitochondrial respiration over anaerobic glycolysis. 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