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Peppermint essential oil is inherently antibacterial, antioxidant, and anti\u2010inflammatory, yet its integration into stable, contact\u2010active coatings is limited by fabrication constraints. Here, we present a one\u2010step atmospheric pressure plasma polymerisation process that converts peppermint essential oil into a conformal, cross\u2010linked coating that preserves precursor\u2010derived functional groups that drive broad bioactivity. While the coating is substrate\u2010independent, we evaluate its bioactive performance within the context of bladder catheterisation as a pilot application. It scavenges up to 90% of reactive species, reduces pro\u2010inflammatory cytokine expression by up to 60%, and increases anti\u2010inflammatory cytokines by up to 50%, while promoting macrophage polarisation toward an M2 phenotype. The coating exhibits intrinsic antibacterial activity, reducing viable bacteria by 90% (Live\/Dead) and 70% (CFUs), attributed to membrane disruption of Gram\u2010negative pathogens. In turn, this interaction potentiates the activity of colistin and levofloxacin, two antibiotics used in catheter\u2010associated urinary tract infection management. Together, these findings establish a stable, multifunctional coating capable of mitigating infection, alleviating inflammation, and enhancing antibiotic performance, while offering a sustainable route for essential\u2010oil\u2010derived biomaterials.<\/jats:p>","DOI":"10.1002\/smll.202510552","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:35:57Z","timestamp":1768826157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Multifunctional Bioactive Nanoscale Coating Deposited by Atmospheric Pressure Plasma Polymerization of Peppermint Essential Oil"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0773-3290","authenticated-orcid":false,"given":"Trong Quan","family":"Luu","sequence":"first","affiliation":[{"name":"Biomedical Nanoengineering Laboratory College of Medicine and Public Health Flinders University  Bedford Park South Australia 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